Download ALI and ARDS: Challenges and Advances, An Issue of Critical by Lena M. Napolitano MD, Krishnan Raghavendran MD PDF

By Lena M. Napolitano MD, Krishnan Raghavendran MD

This factor of serious Care Clinics will specialise in critical Acute respiration misery Syndrome and working with it within the ICU. subject matters will comprise: demanding situations and Successes in ARDS Research;Mechanical air flow with Lung protecting recommendations: What works?; Gene treatment for ALI/ARDS;High Frequency Oscillatory air flow in ALI/ARDS;Prone positioning remedy in ARDS;Recovery and long term consequence in ARDS; and Experimental versions and emergeing hypotheses for ALI and ARDS

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Extra info for ALI and ARDS: Challenges and Advances, An Issue of Critical Care Clinics (The Clinics: Internal Medicine)

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Gross and microscopic findings at autopsy of a patient with H1N1 associated severe ARDS (from University of Michigan). Hemorrhagic pneumonitis with consolidation, edema, and premortem pulmonary thrombi in distal branches of the pulmonary arteries. Micros copy confirms proliferative organizing diffuse alveolar damage with recent hemorrhage. (Hematoxylin and Eosin (H&E) Stain 100 Â Magnification). Pathologic examination of 100 fatal cases in the United States by the Centers for Disease Control and Prevention confirmed that the most prominent histopathological feature observed was diffuse alveolar damage in the lung in all patients examined.

4. Rubenfeld GD, Caldwell E, Granton J, et al. Interobserver variability in applying a radiographic definition for ARDS. Chest 1999;116(5):1347–53. 5. Meade MO, Cook RJ, Guyatt GH, et al. Interobserver variation in interpreting chest radiographs for the diagnosis of acute respiratory distress syndrome. Am J Respir Crit Care Med 2000;161(1):85–90. 6. Wiener RS, Welch HG. Trends in the use of the pulmonary artery catheter in the United States, 1993–2004. JAMA 2007;298(4):423–9. 7. Esteban A, Fernandez-Segoviano P, Frutos-Vivar F, et al.

The study drug will be blinded with an identical-appearing placebo. The first study drug dose (rosuvastatin or placebo) will be administered within 4 hours of randomization as a loading dose of 40 mg followed by maintenance doses of 20 mg 467 468 Thompson & Bernard per day. The primary efficacy measure is hospital mortality to day 60. gov/ct2/show/NCT00979121). REFERENCES 1. Ketoconazole for early treatment of acute lung injury and acute respiratory distress syndrome. A randomized controlled trial.

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